Polynucleotides and wrinkles — what to expect (and what not to)

If you’re searching “polynucleotide serum for wrinkles” or “polynucleotides for fine lines”, you’re probably not looking for vague promises. You want a straight answer: will this actually help, and how long does it take?

This page is written for that moment — when you’re building an anti-ageing routine but you want it to feel realistic. No 12-step “skin cycling” complexity, no dramatic claims. Just a clear explanation of what fine lines are, what typically makes them look worse, and where polynucleotides fit in a routine designed to improve the appearance of lines over time.

New to the category? Start with the pillar guide first: Polynucleotide Skincare Explained: What It Is, How It Works & How to Use It.

Do polynucleotides help with fine lines and wrinkles?

They can — but it helps to understand which lines you’re trying to improve and what your routine is missing.

Most “wrinkles” people notice day-to-day fall into two buckets:

• Dehydration lines (skin looks creased, tight, or crinkly — often worse after travel, cold weather, stress, or a run of strong actives).
• Expression lines / structural lines (areas that crease with movement over years — forehead, crow’s feet, smile lines).

Polynucleotide skincare is typically most helpful for the first bucket — and for improving overall skin quality so the face looks smoother and more “rested”. When skin holds hydration better and the barrier behaves more consistently, fine lines often look less obvious, especially in the morning and under makeup.

Why fine lines appear (and why they look worse some days)

The appearance of fine lines and wrinkles is influenced by more than age alone. Many lines look deeper when skin is:

• Dehydrated (not holding water well)
• Barrier-stressed (tight, reactive, sensitised)
• Over-treated (too many acids/actives too often)
• Under-supported (missing a consistent moisturiser step)

This is why “anti-ageing” routines that are all actives and no structure often backfire. If your skin is constantly irritated, it rarely looks smoother — it just looks busy, dry, and unpredictable.

Where polynucleotides fit in an anti-ageing routine

Think of polynucleotides as the “skin quality” backbone of an anti-ageing routine. Instead of chasing a new active every month, you keep a consistent routine that supports hydration, comfort and the appearance of elasticity — then add stronger actives only if your skin stays stable.

That’s exactly why we built a simple three-product system:

• Foaming Facial Cleansing Gel (preps the skin properly, especially at night)
• Polynucleotide Serum (your daily treatment step)
• Polynucleotide Moisturising Cream (seals hydration + supports the barrier)

If you use devices, you don’t need to reinvent the wheel — you just keep the order clean and repeatable. (More on that below.)

Simple AM routine for smoother-looking skin

Mornings should be quick. The goal is skin that feels comfortable, looks fresh, and doesn’t start the day already irritated.

Simple PM routine for fine lines and wrinkles

Evening is where routines actually earn their keep — because you’re removing SPF, pollution and the day’s buildup. If you do one thing well, do this part consistently.

If you use Radiance Pod: order, pacing and “device nights”

On Radiance Pod days, keep things simple and structured. The device needs proper contact and glide, which is why conductor gel comes before skincare.

If you use the Pure Tone Glow LED Face Mask: layering that stays comfortable

LED is a consistency technology. You’ll get more value from a routine that feels easy to repeat than from heavy layering that makes you skip sessions.

Comparison table: polynucleotides vs HA vs peptides vs retinol (for fine lines)

People often compare ingredients as if one “wins”. In real routines, the better question is: what role does each one play? Here’s a clear way to think about it.

How long until you see changes?

Most people notice the “surface” improvements first — skin feels less tight, makeup sits better, the face looks more consistently hydrated. The deeper-looking changes are slower and tied to routine consistency.

FAQs

Will polynucleotides remove wrinkles?

Skincare is better thought of as “supports the appearance” rather than “removes”. Polynucleotide routines are typically used to improve skin quality — hydration stability, comfort and elasticity appearance — which can make fine lines look less obvious over time, especially dehydration lines.

Which lines respond best: forehead, crow’s feet or smile lines?

Dehydration-related lines anywhere on the face often improve first because the surface is better hydrated and supported. Deeper expression lines tend to be slower and benefit from consistent routine habits over months.

Can I use the polynucleotide serum morning and night?

Yes. Most people use it once or twice daily as the treatment step. If you also use strong actives, introduce gradually and prioritise comfort — irritated skin rarely looks smoother.

I use retinol — where do polynucleotides fit?

Many people use polynucleotides as the consistent “base” routine, then keep retinol on structured nights (for example, a few evenings per week) once the skin feels stable. If your skin becomes dry or sensitive, simplify and rebuild consistency first.

Do I need the moisturiser if my skin is oily?

Often, yes — just use less. Oily skin can still be dehydrated, and dehydration can make fine lines look more obvious. A thin layer of moisturiser helps keep the surface comfortable and more consistent.

Can I use this routine with Radiance Pod?

Yes. Keep the order structured: cleanse first, then apply conductor gel, complete your Radiance Pod session, then finish with serum and moisturiser.

On device nights, avoid piling on strong exfoliating acids. Comfort and consistency win.

Can I use polynucleotide serum with an LED mask?

Yes. After cleansing, apply a light, even layer of serum, complete your LED session, then moisturise. Keep layers comfortable and repeatable so you don’t start skipping sessions.

How much product should I use?

Cleanser: a pea-sized amount is usually enough. Serum: typically 1–2 pumps for face and neck. Moisturiser: an almond-sized amount, adjusting based on your skin’s comfort.

What if my skin feels tight or looks worse at first?

Tightness usually means your barrier is stressed or you’ve introduced too many changes at once. Simplify: cleanse gently, use serum and moisturiser consistently, and pause strong actives until your skin feels stable again.

How do I choose the right route for my skin?

If you want the simplest start, begin with the standalone routine for 2–4 weeks. If you already use devices, keep the order structured and repeatable. For a personalised recommendation, use the Interactive Skin Assessment.